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Neonatal-Perinatal Medicine Fellowship Program

Fellowship Scholarly Activity: Past & Present

Our fellows engage in (and have engaged in) in novel and innovative research projects.

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Fellowship Scholarly Activity: Past & Present

Our fellows engage in (and have engaged in) in novel and innovative research projects.

Current Fellows' Research Projects

Research projects for first-year fellows are determined and developed at the start of the academic year. This year's PGY-4 fellows' research projects will be announced at a later date. Check back for more information as it becomes available.

Second-Year Fellows
The effect of COVID-19 on maternal mental health and the provisions of human milk at discharge for preterm infants
Effect of Post-Death Family Meeting on Parental Bereavement

IAIP-HMGB1 Interaction in LPS-Induced Preterm Sheep Brain Injury

Quality Improvement Research Project:

Delayed Cord Clamping in the PTI

Third-Year Fellows
NIPPV vs CPCP at Equal Mean Airway Pressure (NICA Trial)
Outcomes of Preterm Infants Discharged from the NICU with Child Protective Services (CPS) Involvement
Microglia Cell Culture = Attenuation of pro-inflammatory response to LPS by IAIPs
Pathway of Neuronal Cell Death in Hypoxic-Ischemic Injury and Modifications by IAIPs
 

Quality Improvement Research Projects:

  • Pneumothorax Rates in VLBW Infants 
  • REST Project: Optimizing care for ELBW infants in the first hour following delivery (REST: Rapid Evaluation and Stabilization of tiny infants): A QI initiative
 

Past Fellows' Research Projects

Project Title

Resultant Publication, etc

Association between Dietary Intake and Severe BPD in ELBW infants

 

Quality Improvement Initiative to Improve Admission Temperatures to the NICU

 

Endotracheal Aspirate vs. Distal Protected Catheter in Neonates with VAP and the Impact on Antibiotic Usage

 

Intrapartum Fever/Clinical Chorioamnionitis

 

Association between Neighborhood Risk and the Neurodevelopmental Outcomes of Extreme to Moderate Preterm Infants

 

Project Title

Resultant Publication, etc. 

The role of biglycan and decorin in PPROM

Mennella JM, Underhill LA, Collis S, Lambert-Messerlian GM, Tucker R, Lechner BE. Serum Decorin, Biglycan, and Extracellular Matrix Component Expression in Preterm Birth. Reprod Sci. 2021 Jan;28(1):228-236. doi: 10.1007/s43032-020-00251-1. Epub 202link to Reprod Sci article0 Aug 17. PMID: 32804350; PMCID: PMC7782456.

The role of Chitinase 3-like 1 (Chi3L1) in chorioamnionitis and preterm labor

Najrana T, Mahadeo A, Abu-Eid R, Kreienberg E, Schulte V, Uzun A, Schorl C, Goldberg L, Quesenberry P, Sanchez-Esteban J. Mechanical stretch regulates the expression of specific miRNA in extracellular vesicles released from lung epithelial cells. J Cell Physiol. 2020 Nov;235(11):8210-8223. doi: 10.1002/jcp.29476. Epub 2020 Jan 22. PMID: 31970782; PMCID: PMC7374064.

Bridging Connections: A language intervention study of preterm infants in the NICU

 

Project

Resultant Publication, etc.

Prenatal exposure to perfluoroalkyl substances (PFAS), infant birthweight, and adipocytokines: The HOME Study

Buck CO, Eliot MN, Kelsey KT, Calafat AM, Chen A, Ehrlich S, Lanphear BP, Braun JM. Prenatal exposure to perfluoroalkyl substances and adipocytokines: the HOME Study. Pediatr Res. 2018 Dec;84(6):854-860. doi: 10.1038/s41390-018-0170-1. Epub 2018 Sep 13. PMID: 30250302; PMCID: PMC6933943.

Prenatal exposure to stressful life events and infant breastfeeding: Pregnancy Risk Assessment Monitoring Study

Buck CO, Gjelsvik A, Vivier PM, Monteiro K, Amanullah S. Prenatal Exposure to Stressful Life Events and Infant Breastfeeding. Breastfeed Med. 2018 Jul/Aug;13(6):426-432. doi: 10.1089/bfm.2017.0200. Epub 2018 Jul 9. PMID: 29985635.

Neonatal adipocytokines + growth during childhood

Buck CO, Eliot MN, Kelsey KT, Chen A, Kalkwarf H, Lanphear BP, Braun JM. Neonatal Adipocytokines and Longitudinal Patterns of Childhood Growth. Obesity (Silver Spring). 2019 Aug;27(8):1323-1330. doi: 10.1002/oby.22519. Epub 2019 Jun 14. PMID: 31199076; PMCID: PMC6656611.

Co-leader/Clinical Director: Design + Health

D'Cruz R

Course Director: Biomedical Engineering (Brown) Capstone:

D'Cruz R

patent application for transilluminator device developed as a result of the course

CPAP vs unsynchronized NIPPV at equal MAP

Gupta A

Survey of ventilation practices in the USA and Canada

Gupta A, Keszler M. Survey of Ventilation Practices in the Neonatal Intensive Care Units of the United States and Canada: Use of Volume-Targeted Ventilation and Barriers to Its Use. Am J Perinatol. 2019 Apr;36(5):484-489. doi: 10.1055/s-0038-1669442. Epub 2018 Sep 6. PMID: 30189441.

Use of whole exome sequencing to diagnose a rare case of congenital diarrhea in a newborn

Gupta A, Sanville J, Menz T, Warner N, Muise AM, Fiedler K, Martín MG, Padbury J, Phornphutkul C, Sanchez-Esteban J, Cerezo CS. Application of Whole Exome Sequencing in Congenital Secretory Diarrhea Diagnosis. J Pediatr Gastroenterol Nutr. 2019 Jun;68(6):e106-e108. doi: 10.1097/MPG.0000000000002258. PMID: 30633106.

Bench evaluation of NICU and non-NICU ventilators using an active lung model (ASL 5000)

Gupta A

2018 Project Resultant Publication, etc. 
Ambient noise production by high-frequency neonatal ventilators Goldstein J, Laliberte A, Keszler M. Ambient Noise Production by High-Frequency Neonatal Ventilators. J Pediatr. 2019 Jan;204:157-161. doi: 10.1016/j.jpeds.2018.08.029. Epub 2018 Sep 26. PMID: 30268396.
Hepatic gene expression during the perinatal transition in the rat Hurley E, Zabala V, Boylan JM, Gruppuso PA, Sanders JA. Hepatic Gene Expression During the Perinatal Transition in the Rat. Gene Expr. 2018 Dec 14;19(1):1-13. doi: 10.3727/105221618X15293258688953. Epub 2018 Jun 21. PMID: 29929573; PMCID: PMC6290323.
Evidence of lysosomal biogenesis proteome defect and impaired autophagy in preeclampsia

Nakashima A, Cheng SB, Ikawa M, Yoshimori T, Huber WJ, Menon R, Huang Z, Fierce J, Padbury JF, Sadovsky Y, Saito S, Sharma S. Evidence for lysosomal biogenesis proteome defect and impaired autophagy in preeclampsia. Autophagy. 2020 Oct;16(10):1771-1785. doi: 10.1080/15548627.2019.1707494. Epub 2019 Dec 26. PMID: 31856641

2017 Project Resultant Publication, etc.
Placental findings in newborns with hypoxic-ischemic encephalopathy (HIE) compared to newborns admitted to a NICU Bingham A, Gundogan F, Rand K, Laptook AR. Placental findings among newborns with hypoxic ischemic encephalopathy. J Perinatol. 2019 Apr;39(4):563-570. doi: 10.1038/s41372-019-0334-9. Epub 2019 Feb 15. PMID: 30770878.
Dietary supplementation with medium-chain triglycerides reduces Candida GI colonization in preterm infants Arsenault AB, Gunsalus KTW, Laforce-Nesbitt SS, Przystac L, DeAngelis EJ, Hurley ME, Vorel ES, Tucker R, Matthan NR, Lichtenstein AH, Kumamoto CA, Bliss JM. Dietary Supplementation With Medium-Chain Triglycerides Reduces Candida Gastrointestinal Colonization in Preterm Infants. Pediatr Infect Dis J. 2019 Feb;38(2):164-168. doi: 10.1097/INF.0000000000002042. PMID: 29596218; PMCID: PMC6604858.
Characterization of preterm umbilical cord-derived mesenchymal stromal cells for use in reversal of neonatal lung injury  
   

Innovation in Action!

Ravi D'Cruz, MD, pictured above with students in the Biomedical Engineering program back in 2018, used his background in design (former architect) to engage students in innovative biomedical projects, including development of a transilluminator. Dr. D'Cruz is emblematic of our fellows who reach outside the box to find a research niche that works for them. 

SPOTLIGHT: Ravi D'Cruz, MD; 2019 Fellowship Graduate

Biomedical innovation: Dr. Ravi D'Cruz, a 2019 fellow in neonatal and perinatal medicine at Women and Infants Hospital, worked with Brown biomedical engineering students to design a new device to help doctors perform blood draws and other procedures in the neonatal intensive care unit.

Biomedical engineering capstone class spurs innovation, new devices
Brown University
Providence RI 02912 401-863-1000

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Fellowship Scholarly Activity: Past & Present